Diffusion nuclear magnetic resonance (NMR) spectroscopy is nowadays a well-established technique for characterizing the structure and dynamics of many kinds of physicochemical systems. Typically, this technique relies on pulsed field gradients to label the spatial position of the nuclear spins and infer the molecular diffusion coefficient from their translational displacement over a given time period. As such, pulsed gradient spin echo (PGSE) and, more recently, diffusion ordered NMR spectroscopy (DOSY), have become invaluable tools for: (i) investigating intermolecular interactions; (ii) estimating molecular weight; (iii) analyzing complex mixtures. Combined with High-Resolution Magic Angle Spinning (HR-MAS), which is known to reduce significantly magnetic susceptibility broadenings in heterogeneous samples, diffusion NMR can be readily applied to both liquid and semi-solid samples. In this communication, several applications of diffusion NMR along the three above-mentioned axes will be reported.